Has anyone used the non SCS rear derailleur hanger on their bikes to run non scs hubs? If so any issues? My bike is going to need new wheels and looking at some Mavics.

Yes, which model bike?

I ran it on a roubaix sl4 that was QR & it was fine.

On my Diverge that is 135×12 the axle is a bit shorter through the frame than with the scs hanger. I’m running zipp wheels but thinking of buying a 142×12 axle & trimming it down a bit at work if needs be so it goes a bit further into the frame

Its a carbon Camber. Interesting it worked on your SL4 as i’ve also got a DSW Diverge, it will also need a wheel upgrade at some point that also is SCS.