He uses some funny scales, lots of chromatic ups and downs rather than mind-melting mixylodian modes so don’t panic. Also dropped D tuning as mentioned above.
You need 2 volume controls on your guitar and an easy-to-reach toggle switch for the on-off bits, so if you like your fender types you’ll be in for a bit of rewiring!
And for a couple of songs iirc, a double locking (floyd rose) tremelo which means you will end up staying in dropped D all the time because tuning the low e up and down all makes all your other strings go in and out of tune. The ‘proper’ morello fanboi guitar setup is a bit of a faff then!
I found this page which might help with tunings and fx noises….
…which of course means the most excellent digitech whammy pedal. This is pretty cheap if you buy into a digitech multi fx unit with an expression pedal, (lost track of what is current, but even if you buy an old and now very cheap one like the RP3/6/9 you can have a play around and see if you like it. Oh be warned, old digitech needs AC/AC power supply so check befire you buy) I would definitely buy a proper dunlop crybaby though, bestest pedal EVER.
Or purists/fans can pay daft money on ebay for the original red one.