Keep a check on your mental health.
From Learned Optimism, the three signs of depressive thinking are Personal, Pervasive and Permanent.
So you get a job rejection or no reply at all, there are many different 'take home messages'.
The optimist would say 'Well they were inundated with applications and just didn't have time to reply to them all'. This is an impersonal message, nothing bad implied to the person.
Examples of depressive thinking take home messages are:
'My CV must have been terrible' - this is personal
'They rejected me, so everyone will reject me' - this is Permanent - ie extrapolating one rejection to all possible future rejections.
'They rejected me, I'm no good as an employee and as a person' - this is pervasive, extrapolating one rejection to other aspects of life.
The trick is to keep negative things in their box and not let them become pervasive, personal or permanent.