Many years ago, when I was single and had disposable income, I had an Orange E2 with a Royce Ti BB and Middleburn cranks (would they have been RS2s?). They worked like a dream at first but at some point started creaking: I never worked out if this was because the cranks had worked themselves loose and I’d then opened up the taper, or there was a Ti:Aluminium problem with the frame, or something else – this was long before the days of asking for opinions on internet fora. Anyway, despite a very enjoyable afternoon spent at Royce, trying to solve the problem with Cliff (who was astoundingly helpful) I never satisfactorily fixed it. In the end the bike was stolen, so some thieving scumbag inherited the problem.
It wouldn’t put me off doing the same again if I had the money, but I’d certainly keep a close eye on the crank bolt tightness…