I've loved my Ksyrium Elites, very strong, stiff and light. But I hit a pothole and they didn't fare well. I also love my handbuilts; Miche track hubs, Sapim laser spokes and Open Pros. I hit a pothole and split the Open Pro rim this week. The wheel is not round, but it stayed true and didn't pinch flat. Rim is being replaced with another Open Pro.
Kysyrium are being replaced with a nice pair of high end handbuilts for general riding to complement the carbon low profiles I use for racing. For general riding, it's handbuilts for me now, every time.
There is more to ride quality than a 100g weight saving. Choose some light tyres and add Conti race inner tubes - that will save a 100g a wheel.