Good to see you're coming over to the darkside!
The important thing is finding a comfortable, well balanced position on your steed.
It's taken me plenty of hours to find a setup that looks good in photos, but I reckon I've just about cracked it (130mm stem, slammed FWIW).
I tend to ride mine for upto ninety minutes at a time, prowling the popular routes looking for other lads to ride faster than. For this length of ride its fine, any longer then it might be uncomfortable, but I usually stop at the cafe after ninety minutes (if I'm out for a full day I can end up stopping upto five times).
At the cafe (a popular haunt for cyclists), my setup comes into its own - one hundred and thirty mils worth of slammed stem. 15cm of bar drop. The other cyclists immediately suspect its me that's thrashed past them at high pace, just by looking at my bike. Lots of admiring glances, especially if I'm wearing team kit.
I play along to it though, and offer free setup advice to the other cyclists who are looking for any performance gain. It's proved popular and the cafe has started providing me with free coffee. Win!