I find that too much padding can bunch up creating hotspots too.
I have Carpal Tunnel in both wrists and struggle with pins and needles in my index, middle and thumbs. The specialised gloves have a pad which protects the Ulnar nerve (3rd and pinky fingers) so if that’s where you’re getting the pins and needles then they would be worth a look.
My current set up is minimal or no gloves and ESI chunky grips, this is a bit of a sweet spot for me, I used a spare set of gloves a couple of weeks ago which have a thicker and slightly stiffer palm and started to struggle after 15 miles.
Also take a look at how you’re holding the bars, I find that if mine aren’t set up right I don’t grip the bar straight across my hand, so end up with all the pressure concentrated on a small area.
Ergon grips seem well respected too, although I couldn’t get on with them.