great plan - sounds practically the same as our honeymoon (we were married 21-10, so in SFO from 23rd on): SF, Sonoma Valley vineyards to Sacramento (not worth visiting but was an ideal motel stop off on the way to Tahoe); Tahoe,
And then it went wrong......
Woke up in the morning in Sth Lake Tahoe, looked out the window and said to the wife 'It's snowed in the night'. Nice, says she; Erm.... proper snow said I. Like 2 foot. Completely scuppered our plans to go into Yosemite and over Tioga and through Death Valley, but did lead to an interesting conversation with the State Trooper checking if we had snow chains - we told him our plans and asked when the snow would thaw enough to make Tioga passable again. After he stopped laughing, he estimated April. And then redirected us around the bottom of the Sierra Nevada mtns, through a number of silver rush genuine ghost towns, which weren't on the original plan but were amazing, before finally picking up the main LA-LV road at Barstow. Point of this story - have a plan B.
For LV itself - we got a helicopter ride with Papillon helicopters; they have a deal with an Indian tribe that allows them to not only fly over their lands but actually land in the Grand Canyon, 4000ft below the rim, and have a champagne picnic on the banks of the Colorado river. The concierge at your hotel can book it, ours also advised us to take a late flight (our plan originally was for earlyish to free up the rest of the day) but it meant that we got to see the GC in sunset colours, and then LV strip at night, with Elvis on the in flight stereo! Pure cheese, pure brilliance.
Carmel is charming if a bit twee, but Clint is/was Mayor so don't say it out loud or he'll bust you up. Monterey is a bit disappointing TBH but some great fish restaurants on Cannery Row, get the little sand dabs if you can. Pacific Coast highway is a great drive, past Big Sur, maybe see whales (we didn't). And maybe visit Hearst Castle (you need to book in advance, which is just awesome in an American OTT type way) - like the best bits of all European stately homes / architecture thrown together into one house.