Yeah, I’ve worked for years in both cities. I’ll be biased though because I’m local to Manchester but I certainly find a lot more that suits me up North. London is good for going out and doing stuff when you first get there but for me it was not long before I wanted to see hills and fields, something you can easily achieve in most tall buildings in Manchester.
Lot easier to get out of the city, and most people who work in Manchester, don’t live in Manchester so they’re not focussed on the city quite so much. Works for me.
edit: A’ll add that that last point about people not living in the city, is changing. Over the last ten years or so Manchester centre has been made a lot more acceptable to Yuppies (the bombs certainly helped kickstart the regeneration) so I expect Manchester will eventually follow London for that trend.