Shaw was carried off on a stretcher while receiving oxygen after a tackle from behind by Hector Moreno in the 15th minute. United confirmed the left-back’s injury was incredibly serious after the match.
A United spokesperson said: “Luke Shaw has suffered a double fracture of the leg.”
Shaw will now be transferred to Manchester to be operated on.
With the score at 0-0, the United left-back was the subject of a sliding tackle by Hector Moreno in the 15th minute of the group stage match in Holland. Replays showed Moreno had swept both of Shaw’s feet from underneath him and his right foot lay at an angle, which indicated a break.