It’s not so much the ISM needs breaking in like a leather brooks, it’s more you need to adapt to it.
I got my first one from http://www.trybikestore.co.uk/
I had a hydrocele which made riding a bike very uncomfortable.
Trybikestore do a 14 day free trial, so I thought I might as well give it a go.
For my specific problem at that time, it was ideal and got me back to riding a bike again.
I’ve had the operation and everything’s back to normal now, but I liked the seat so much I bought them for my cross bike and tandem as well.
It feels like a plank of wood at first. It really is worth persevering for the 14 day trial though as you do get used to it.
I’m waiting for another one to turn up cheap on ebay. In the mean time, whenever I ride my spare mountain bike, it feels really odd having the seat contact me in the wrong place.
I rode 15 hours in total at Bristol last weekend and was able to sit a lot more than I ever have on a traditional saddle.