I agree with the others. I'm based at home but have to go into the office sometimes which is 2 hours away - a few days of that back-to-back really grates. Doing it every day, week in week out, is madness. In the summer it's not so bad - in the winter you leave and return in the dark every day. Every weekday feels like you get up, drive, work, drive, quickly grab some dinner then get to bed early as you have to be up so early the next day. Weekends you're so drained from the week that you don't want to do anything, especially not drive anyway.
Assuming it's a 80 mile commute, that's 40k miles a year. You'll be having to get your car serviced or new tyres every few months. Even if you had a diesel that does a genuine 50mpg, that's well over £4000 a year in fuel. Any car you have will either depreciate like a stone, or if it's older, need constant running repairs. Your exposure to an accident increases a fair bit too.
If it's a dream job and you're able to make the other stuff work, be a little selfish and relocate.
