I put el cheapo tektro mini vs on a cross bike- clearance wasn’t quite as good as cantis and the straddle wire caused a little hassle if I fitted mudguards for commuting, but those were the only downsides- I’ve used really expensive cantis that the owners swore were the mutt’s nuts and they performed worse than these did on their OEM (rubbish) pads.
Possibly becomes more of an issue if you race- they weren’t especially cloggy (the clearance through the frame and forks was less than the brakes, though it is not quite that simple) so it was only a problem on proper bad mud, which was rotten anyway. So that side never did affect me but it could do someone else.
Oh aye, that was on 5600 105s, and no problem solvers- but the pad clearance wasn’t great, you had to undo the barrel adjuster to get enough room to remove wheels. Either that or have a lot of lever play. So I did the barrel thing, no real bother.