Yes, if you like Hope brakes and happy bleeding/maintaining them, and have spare hose/fittings/Dot 5.1 bleed kit it makes good sense to carry this over to your CX bike.
Very happy with my V-Twins. I’m running them with 105 5700 levers.
Compared to running X2 calipers with Tech/Race levers, V-Twins are not as sensitive, so you do need to pull the levers harder than dedicated road hydraulic brakes. Quite simply, the V-Twin cylinder/piston design isn’t as efficient as its MTB cousin. This is noticeable when operating the brakes while holding the hood, but once on the drops, you can lock out either wheel no problem, at which point you realise they’re as powerful as you’ll ever need on a cross bike. And as modulation is excellent (i.e. never ‘grabby’) you can always brake in confidence on the slippiest offcamber sections.
The main benefits are that they’re MTB brakes through and through. This means they’re tough, you can run metallic sintered pads, no need for that pad cooling fin nonsense. Bleeding is exactly the same as MTB brakes – the master cylinders are actually just modified Minis.
It’s also great that you can mix and match calipers. My previous CX bike had IS tabs, so I fitted old mono calipers (no adaptors needed) with my V-Twin master cylinder, and they worked perfectly. My new frame has PM mounts, so I’ve ‘retrieved’ the X2 calipers back from my MTB. If I wanted to, I could even run E4 calipers with the V-Twin on the CX bike, but that might be overkill.