24 is not insignificant and is very noticeable! Everyone has a personal preference and what suits them.
But that’s my point: Unless you get a bike that is custom built to your exact dimensions then there will always be an element of fiddling around with your position. I would say 25mm is actually a small amount of adjustment when spread between saddle position, stem length, and handlebar rotation.
@Renton: Looking at the Giant size chart, 6ft 2 is slap bang in the middle of the range for the large. XL would be too big, unless you have disproportionally long arms and legs. Similarly, medium looks like it would be too small, unless you have disproportionally short arms and legs.