I'm ~150lb. I've had crest rimmed wheels on my 26" FS and now my HT, for 18 months, run with Dampf 2.35 snakeskin tyres. Esp. the rear on the HT they have had a battering. The rear knocked out of shape a bit in-use and needed some truing but there has been no crash damage AFAIK. I've crashed occasionally so maybe I've been lucky, or maybe the tyres are doing a good job of protecting them.
The main issue is that they deflect quite a bit, in the rough, in corners, and when standing up pedalling. But the pay-off is that you feel the benefit of the low weight when you kick the pedals.