had a similar thing with my crap setup at home. Basically after replacing a rad the system cant be filled from the tank in the loft. the reason is several. there are bends in the feed so we get air locks and we also have magnetite in the system which can block it up.
we had a plumber here for 4 hours last time and he gave up trying to get it going!
I have 2 methods now. one is to fill an old fire extingisher with water. pressurise it to 50psi and force water into the headertank outlet. you could do this with a hose. secondly i reverse fill it from the bottom rad.
before this however open all valves on the rads fully (both sides) and give it some time (an hour to settle) then try switching it on and off a few times (pump) to see if you can shift any airlocks.
it can be a time consuming thing. also dont do it when it snows like i did 🙁