Ergon – I much prefer it to my previous Deuter / Osprey attempts to find a decent day bag and that is also big enough to carry things to and from work once or twice a week (laptop / clothes etc). It's got a pouch for a bladder as well as routing on the straps for the tubes.
It sits off your back which means you don't get too hot, the weight sits nicely on your hips and the ball joint means that you've got pretty free movement and don't get any disconcerting weight shifts when it's fully laden. Mine's withstood over a year of use through pretty grim weather and I've never had a problem with leaks etc when using the waterproof cover.
Expensive though.