Why a 10spd rear casette? A 9spd or 8spd will cover the range just fine
It depends, if you're only riding on smoother stuff (no stairs/rough stuff/drops/jumps) then with an unramped (dedicated single ring) front chainring you can get away with no type of chainguiding providing the chainline is in the middle
You may need a chain device of some sort though. Whether it be a bashring and an N-gear jump stop or something else to stop the chain from falling off on the inside or a full on 4X/DH race type guide/roller device
A front mech will guide it just fine too, but isn't the most tidy, but will work for you to try out