Southern half of the route wouldn’t appeal to me much TBH. There’s a load of quite dangerous (IMO) bits of the A65, and the bit south of Skipton is not a particularly pleasant way to end an epic ride. Is there any reason why Bradford is the destination of choice?
Why not head towards Kirkby Stephen, and ride down to Settle via Ribblehead? There would a bit more climbing, but not a desperate amount, some fantastic scenery too, and you would almost entirely avoid the A65. You could also ride some smaller roads on the south side of the A65.
It also gives you some bailout stations at KS, Garsdale, Horton etc if things go horribly wrong.
PS The hill out of Settle will be a bit of a killer after that mileage, but possibly a necessary evil.